The theory stating that oxidative stress is at the root of several diseases is extremely popular. However, so far, no antioxidant is recommended or offered by healthcare systems neither approved as therapy by regulatory agencies that base their decisions on evidence-based medicine. This is simply because, so far, despite many preclinical and clinical studies indicating a beneficial effect of antioxidants in many disease conditions, randomised clinical trials have failed to provide the evidence of efficacy required for drug approval. In this (...) review, we discuss the levels of evidence required to claim causality in preclinical research on OS, the weakness of the oversimplification associated with OS theory of disease and the importance of the narrative in its popularity. Finally, from a more translational perspective, we discuss the reasons why antioxidants acting by scavenging reactive oxygen species might not only prevent their detrimental effects but also interfere with essential signalling roles. We propose that ROS have a complex metabolism and are generated by different enzymes at diverse sites and with different timing. Aggregating this plurality of systems in a single theory of disease may not be the best way to develop new drugs, and future research may need to focus on specific oxygen-toxifying pathways rather than on non-specific ROS scavengers. Finally, similarly to what is nowadays required for clinical trials, we recommend making unpublished data available in repositories, as this will allow big data approaches or meta-analyses without the blinders of the publication bias. (shrink)

Friedrich Engels: Herrn Eugen Dührings Umwälzung der Wissenschaft. (Anti-Dühring) Lesefreundlicher Großdruck in 16-pt-Schrift Großformat, 210 x 297 mm Berliner Ausgabe, 2019 Durchgesehener Neusatz mit einer Biographie des Autors bearbeitet und eingerichtet von Theodor Borken Erstdruck in: Vorwärts (Leipzig), 3.1.1877 - 7.7.1878. Erste Buchausgabe, Leipzig 1878. Der Text folgt der letzten von Engels durchgesehenen und vermehrten Ausgabe, Stuttgart (J.H.W. Dietz) 1894. Textgrundlage ist die Ausgabe: Karl Marx, Friedrich Engels: Werke. Herausgegeben vom Institut für Marxismus-Leninismus beim ZK der SED, 43 Bände, Band (...) 20, Berlin: Dietz-Verlag, 1962. Umschlaggestaltung von Thomas Schultz-Overhage. Gesetzt aus der Minion Pro, 16 pt. Henricus Edition Deutsche Klassik UG (haftungsbeschränkt). (shrink)

Existential-Ontologie und historischer Materialismus bei Herbert Marcuse, von A. Schmidt.--Das Ganze und das ganz Andere; zur Kritik der reinen revolutionären Transzendenz, von W.F. Haug.--Technik und Eindimensionalität; eine Version der Technokratiethese? Von C. Offe.--Technologische Rationalität und spätkapitalistische ökonomie, von J. Bergmann.--Die geschichtliche Dimension des Realitätsprinzips, von H. Berndt und R. Reiche.--Marcuse and the New Left in America, by P. Breines.--Ausgewählte Bibliographie der Schriften Herbert Marcuses (p. 155-[161]).

Recently proposed models of risky choice imply systematic violations of transitivity of preference. This study explored whether people show the predicted intransitivity of the two models proposed to account for the certainty effect in Allais paradoxes. In order to distinguish “true” violations from those produced by “error,” a model was fit in which each choice can have a different error rate and each person can have a different pattern of preferences that need not be transitive. Error rate for a choice (...) is estimated from preference reversals between repeated presentations of the same choice. Results showed that few people repeated intransitive patterns. We can retain the hypothesis that all participants were transitive. (shrink)

Nad barjem je veter in moker je zrak, uši imam v tuniki, v nosu prehlad. Z neba štropotajo nalivi dežja, vojak sem na zidu, ne vem sploh, zakaj. Po sivem kaménju se plazi megla, dekle imam v Tungriji, jaz pa spim sam.